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Spravato® (esketamine)

Spravato is a proven life changing FDA approved esketamine therapy for treatment resistant major depressive disorder.  The medication is a prescription nasal spray administered by certified  clinical staff.  Spravato was developed for people 18 years of age and older who need rapid relief from suicidal thoughts or treatment failure with traditional antidepressants (SSRI’s/SNRI’s) which work on monoaminergic neurotransmitters (serotonin, dopamine, and norepinephrine).  The mechanism in which Spravato is believed to target is the brain’s glutamate system by blocking NMDA receptors which allows for more widespread impact on brain cells.  This results in increasing neural connections which rewires circuits in the brain to form new more positive thinking patterns.  The glutamingeric system is a promising target for a novel emerging treatment for mental health disorders. 

Spravato provides a significant advancement in depression treatment.

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